Publications

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All Okkenhaug publications (lab members in bold):

Whiteside, SK, Grant, FM, Alvisi, G, Clarke, J, Tang, L, Imianowski, CJ et al.. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T_reg depletion. Sci Immunol. 2023;8 (90):eabo5558. doi: 10.1126/sciimmunol.abo5558. PubMed PMID:38100544 PubMed Central PMC7615475.

Suchanek, O, Ferdinand, JR, Tuong, ZK, Wijeyesinghe, S, Chandra, A, Clauder, AK et al.. Tissue-resident B cells orchestrate macrophage polarisation and function. Nat Commun. 2023;14 (1):7081. doi: 10.1038/s41467-023-42625-4. PubMed PMID:37925420 PubMed Central PMC10625551.

Johansen, KH, Golec, DP, Okkenhaug, K, Schwartzberg, PL. Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion. Trends Immunol. 2023;44 (11):917-931. doi: 10.1016/j.it.2023.09.002. PubMed PMID:37858490 PubMed Central PMC10621891.

Stewart, H, Palmulli, R, Johansen, KH, McGovern, N, Shehata, OM, Carnell, GW et al.. Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release. EMBO Rep. 2023;24 (12):e57224. doi: 10.15252/embr.202357224. PubMed PMID:37818801 PubMed Central PMC10702813.

Begg, M, Amour, A, Jarvis, E, Tang, T, Franco, SS, Want, A et al.. An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome. Pulm Pharmacol Ther. 2023;79 :102201. doi: 10.1016/j.pupt.2023.102201. PubMed PMID:36841351 .

Imianowski, CJ, Whiteside, SK, Lozano, T, Evans, AC, Benson, JD, Courreges, CJF et al.. BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis. J Exp Med. 2022;219 (12):. doi: 10.1084/jem.20211476. PubMed PMID:36178457 PubMed Central PMC9529614.

Johansen, KH, Golec, DP, Huang, B, Park, C, Thomsen, JH, Preite, S et al.. A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells. Sci Signal. 2022;15 (743):eabl9169. doi: 10.1126/scisignal.abl9169. PubMed PMID:35857633 PubMed Central PMC9637254.

Eschweiler, S, Ramírez-Suástegui, C, Li, Y, King, E, Chudley, L, Thomas, J et al.. Intermittent PI3Kδ inhibition sustains anti-tumour immunity and curbs irAEs. Nature. 2022;605 (7911):741-746. doi: 10.1038/s41586-022-04685-2. PubMed PMID:35508656 PubMed Central PMC9132770.

Serra, I, Manusama, OR, Kaiser, FMP, Floriano, II, Wahl, L, van der Zalm, C et al.. Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model. Brain Behav Immun Health. 2021;18 :100377. doi: 10.1016/j.bbih.2021.100377. PubMed PMID:34786564 PubMed Central PMC8579111.

Johansen, KH, Golec, DP, Thomsen, JH, Schwartzberg, PL, Okkenhaug, K. PI3K in T Cell Adhesion and Trafficking. Front Immunol. 2021;12 :708908. doi: 10.3389/fimmu.2021.708908. PubMed PMID:34421914 PubMed Central PMC8377255.

Pantarelli, C, Pan, D, Chetwynd, S, Stark, AK, Hornigold, K, Machin, P et al.. The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection. Blood Adv. 2021;5 (16):3076-3091. doi: 10.1182/bloodadvances.2020002782. PubMed PMID:34402884 PubMed Central PMC8405187.

Okkenhaug, K. How to resist PI3Kδ inhibition: activate MAPK!. Blood. 2021;138 (1):3-4. doi: 10.1182/blood.2021011365. PubMed PMID:34236428 .

Vanhaesebroeck, B, Perry, MWD, Brown, JR, André, F, Okkenhaug, K. PI3K inhibitors are finally coming of age. Nat Rev Drug Discov. 2021;20 (10):741-769. doi: 10.1038/s41573-021-00209-1. PubMed PMID:34127844 PubMed Central PMC9297732.

Whiteside, SK, Grant, FM, Gyori, DS, Conti, AG, Imianowski, CJ, Kuo, P et al.. CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function. Immunology. 2021;163 (4):512-520. doi: 10.1111/imm.13337. PubMed PMID:33838058 PubMed Central PMC8274197.

Luff, DH, Wojdyla, K, Oxley, D, Chessa, T, Hudson, K, Hawkins, PT et al.. PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4⁺ T Cells. Front Immunol. 2021;12 :631271. doi: 10.3389/fimmu.2021.631271. PubMed PMID:33763075 PubMed Central PMC7982423.

Stewart, H, Palmulli, R, Johansen, KH, McGovern, N, Shehata, OM, Carnell, GW et al.. Tetherin antagonism by SARS-CoV-2 enhances virus release: multiple mechanisms including ORF3a-mediated defective retrograde traffic. bioRxiv. 2022; :. doi: 10.1101/2021.01.06.425396. PubMed PMID:33442692 PubMed Central PMC7805449.

Iacono, A, Pompa, A, De Marchis, F, Panfili, E, Greco, FA, Coletti, A et al.. Class IA PI3Ks regulate subcellular and functional dynamics of IDO1. EMBO Rep. 2020;21 (12):e49756. doi: 10.15252/embr.201949756. PubMed PMID:33159421 PubMed Central PMC7726814.

Vardaka, P, Lozano, T, Bot, C, Ellery, J, Whiteside, SK, Imianowski, CJ et al.. A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2. Sci Rep. 2020;10 (1):18902. doi: 10.1038/s41598-020-75732-z. PubMed PMID:33144667 PubMed Central PMC7641119.

Lau, D, Garçon, F, Chandra, A, Lechermann, LM, Aloj, L, Chilvers, ER et al.. Intravital Imaging of Adoptive T-Cell Morphology, Mobility and Trafficking Following Immune Checkpoint Inhibition in a Mouse Melanoma Model. Front Immunol. 2020;11 :1514. doi: 10.3389/fimmu.2020.01514. PubMed PMID:32793206 PubMed Central PMC7387409.

Mahata, B, Pramanik, J, van der Weyden, L, Polanski, K, Kar, G, Riedel, A et al.. Tumors induce de novo steroid biosynthesis in T cells to evade immunity. Nat Commun. 2020;11 (1):3588. doi: 10.1038/s41467-020-17339-6. PubMed PMID:32680985 PubMed Central PMC7368057.

Bibby, JA, Purvis, HA, Hayday, T, Chandra, A, Okkenhaug, K, Rosenzweig, S et al.. Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate. Nat Commun. 2020;11 (1):3412. doi: 10.1038/s41467-020-17179-4. PubMed PMID:32641742 PubMed Central PMC7343868.

Wood, AJ, Vassallo, AM, Ruchaud-Sparagano, MH, Scott, J, Zinnato, C, Gonzalez-Tejedo, C et al.. C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodeling. JCI Insight. 2020;5 (15):. doi: 10.1172/jci.insight.137029. PubMed PMID:32634128 PubMed Central PMC7455072.

Nieuwenhuis, B, Barber, AC, Evans, RS, Pearson, CS, Fuchs, J, MacQueen, AR et al.. PI 3-kinase delta enhances axonal PIP₃ to support axon regeneration in the adult CNS. EMBO Mol Med. 2020;12 (8):e11674. doi: 10.15252/emmm.201911674. PubMed PMID:32558386 PubMed Central PMC7411663.

Grant, FM, Yang, J, Nasrallah, R, Clarke, J, Sadiyah, F, Whiteside, SK et al.. BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression. J Exp Med. 2020;217 (9):. doi: 10.1084/jem.20190711. PubMed PMID:32515782 PubMed Central PMC7478731.

Stark, AK, Davenport, ECM, Patton, DT, Scudamore, CL, Vanhaesebroeck, B, Veldhoen, M et al.. Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation. J Immunol. 2020;205 (1):78-89. doi: 10.4049/jimmunol.2000043. PubMed PMID:32414808 PubMed Central PMC7311201.

Papapietro, O, Chandra, A, Eletto, D, Inglott, S, Plagnol, V, Curtis, J et al.. Topoisomerase 2β mutation impairs early B-cell development. Blood. 2020;135 (17):1497-1501. doi: 10.1182/blood.2019003299. PubMed PMID:32128574 PubMed Central PMC7612232.

Lee, CQE, Bailey, A, Lopez-Tello, J, Sferruzzi-Perri, AN, Okkenhaug, K, Moffett, A et al.. Inhibition of Phosphoinositide-3-Kinase Signaling Promotes the Stem Cell State of Trophoblast. Stem Cells. 2019;37 (10):1307-1318. doi: 10.1002/stem.3052. PubMed PMID:31233251 .

Lim, EL, Okkenhaug, K. Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy. Immunology. 2019;157 (3):210-218. doi: 10.1111/imm.13082. PubMed PMID:31107985 PubMed Central PMC6587315.

Swan, DJ, Aschenbrenner, D, Lamb, CA, Chakraborty, K, Clark, J, Pandey, S et al.. Immunodeficiency, autoimmune thrombocytopenia and enterocolitis caused by autosomal recessive deficiency of PIK3CD-encoded phosphoinositide 3-kinase δ. Haematologica. 2019;104 (10):e483-e486. doi: 10.3324/haematol.2018.208397. PubMed PMID:31073077 PubMed Central PMC6886442.

Paz, K, Flynn, R, Du, J, Tannheimer, S, Johnson, AJ, Dong, S et al.. Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease. Am J Transplant. 2019;19 (6):1820-1830. doi: 10.1111/ajt.15305. PubMed PMID:30748099 PubMed Central PMC6538456.

Chellappa, S, Kushekhar, K, Munthe, LA, Tjønnfjord, GE, Aandahl, EM, Okkenhaug, K et al.. The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function. J Immunol. 2019;202 (5):1397-1405. doi: 10.4049/jimmunol.1701703. PubMed PMID:30692213 .

Stark, AK, Chandra, A, Chakraborty, K, Alam, R, Carbonaro, V, Clark, J et al.. PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner. Nat Commun. 2018;9 (1):3174. doi: 10.1038/s41467-018-05674-8. PubMed PMID:30093657 PubMed Central PMC6085315.

Gyori, D, Lim, EL, Grant, FM, Spensberger, D, Roychoudhuri, R, Shuttleworth, SJ et al.. Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy. JCI Insight. 2018;3 (11):. doi: 10.1172/jci.insight.120631. PubMed PMID:29875321 PubMed Central PMC6124419.

Lim, EL, Cugliandolo, FM, Rosner, DR, Gyori, D, Roychoudhuri, R, Okkenhaug, K et al.. Phosphoinositide 3-kinase δ inhibition promotes antitumor responses but antagonizes checkpoint inhibitors. JCI Insight. 2018;3 (11):. doi: 10.1172/jci.insight.120626. PubMed PMID:29875319 PubMed Central PMC6124416.

Benson, RA, Garcon, F, Recino, A, Ferdinand, JR, Clatworthy, MR, Waldmann, H et al.. Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes. Front Immunol. 2018;9 :1006. doi: 10.3389/fimmu.2018.01006. PubMed PMID:29867981 PubMed Central PMC5968092.

Abdelrasoul, H, Werner, M, Setz, CS, Okkenhaug, K, Jumaa, H. PI3K induces B-cell development and regulates B cell identity. Sci Rep. 2018;8 (1):1327. doi: 10.1038/s41598-018-19460-5. PubMed PMID:29358580 PubMed Central PMC5778048.

Kishore, M, Cheung, KCP, Fu, H, Bonacina, F, Wang, G, Coe, D et al.. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis. Immunity. 2017;47 (5):875-889.e10. doi: 10.1016/j.immuni.2017.10.017. PubMed PMID:29166588 PubMed Central PMC5714502.

Stubbs, TM, Bonder, MJ, Stark, AK, Krueger, F, BI Ageing Clock Team, von Meyenn, F et al.. Multi-tissue DNA methylation age predictor in mouse. Genome Biol. 2017;18 (1):68. doi: 10.1186/s13059-017-1203-5. PubMed PMID:28399939 PubMed Central PMC5389178.

Mauro, C, Smith, J, Cucchi, D, Coe, D, Fu, H, Bonacina, F et al.. Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4⁺ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals. Cell Metab. 2017;25 (3):593-609. doi: 10.1016/j.cmet.2017.01.008. PubMed PMID:28190771 PubMed Central PMC5355363.

Lucas, CL, Chandra, A, Nejentsev, S, Condliffe, AM, Okkenhaug, K. PI3Kδ and primary immunodeficiencies. Nat Rev Immunol. 2016;16 (11):702-714. doi: 10.1038/nri.2016.93. PubMed PMID:27616589 PubMed Central PMC5291318.

Okkenhaug, K, Graupera, M, Vanhaesebroeck, B. Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy. Cancer Discov. 2016;6 (10):1090-1105. doi: 10.1158/2159-8290.CD-16-0716. PubMed PMID:27655435 PubMed Central PMC5293166.

Eil, R, Vodnala, SK, Clever, D, Klebanoff, CA, Sukumar, M, Pan, JH et al.. Ionic immune suppression within the tumour microenvironment limits T cell effector function. Nature. 2016;537 (7621):539-543. doi: 10.1038/nature19364. PubMed PMID:27626381 PubMed Central PMC5204372.

Coulter, TI, Chandra, A, Bacon, CM, Babar, J, Curtis, J, Screaton, N et al.. Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study. J Allergy Clin Immunol. 2017;139 (2):597-606.e4. doi: 10.1016/j.jaci.2016.06.021. PubMed PMID:27555459 PubMed Central PMC5292996.

Roychoudhuri, R, Clever, D, Li, P, Wakabayashi, Y, Quinn, KM, Klebanoff, CA et al.. BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers. Nat Immunol. 2016;17 (7):851-860. doi: 10.1038/ni.3441. PubMed PMID:27158840 PubMed Central PMC4918801.

Barbera Betancourt, A, Emery, JL, Recino, A, Wong, FS, Cooke, A, Okkenhaug, K et al.. Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production. PLoS One. 2016;11 (1):e0146516. doi: 10.1371/journal.pone.0146516. PubMed PMID:26783747 PubMed Central PMC4718552.

Garçon, F, Okkenhaug, K. PI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1. Immunol Cell Biol. 2016;94 (5):486-95. doi: 10.1038/icb.2016.1. PubMed PMID:26740009 PubMed Central PMC4829101.

Roychoudhuri, R, Eil, RL, Clever, D, Klebanoff, CA, Sukumar, M, Grant, FM et al.. The transcription factor BACH2 promotes tumor immunosuppression. J Clin Invest. 2016;126 (2):599-604. doi: 10.1172/JCI82884. PubMed PMID:26731475 PubMed Central PMC4731158.

Okkenhaug, K, Roychoudhuri, R. Oncogenic PI3Kα promotes multipotency in breast epithelial cells. Sci Signal. 2015;8 (401):pe3. doi: 10.1126/scisignal.aad5856. PubMed PMID:26535006 PubMed Central PMC4637986.

Okkenhaug, K, Burger, JA. PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL). Curr Top Microbiol Immunol. 2016;393 :123-142. doi: 10.1007/82_2015_484. PubMed PMID:26350103 PubMed Central PMC4704136.

Sauer, K, Okkenhaug, K. Editorial: Lipid Signaling in T Cell Development and Function. Front Immunol. 2015;6 :410. doi: 10.3389/fimmu.2015.00410. PubMed PMID:26322043 PubMed Central PMC4530596.

Pearce, VQ, Bouabe, H, MacQueen, AR, Carbonaro, V, Okkenhaug, K. PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes. J Immunol. 2015;195 (7):3206-17. doi: 10.4049/jimmunol.1501227. PubMed PMID:26311905 PubMed Central PMC4574522.

Browning, MJ, Chandra, A, Carbonaro, V, Okkenhaug, K, Barwell, J. Cowden's syndrome with immunodeficiency. J Med Genet. 2015;52 (12):856-9. doi: 10.1136/jmedgenet-2015-103266. PubMed PMID:26246517 PubMed Central PMC4661225.

Stark, AK, Sriskantharajah, S, Hessel, EM, Okkenhaug, K. PI3K inhibitors in inflammation, autoimmunity and cancer. Curr Opin Pharmacol. 2015;23 :82-91. doi: 10.1016/j.coph.2015.05.017. PubMed PMID:26093105 PubMed Central PMC4518027.

Doisne, JM, Hüber, CM, Okkenhaug, K, Colucci, F. Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation. Cell Rep. 2015;10 (5):702-710. doi: 10.1016/j.celrep.2015.01.002. PubMed PMID:25660021 PubMed Central PMC4542309.

Okkenhaug, K, Turner, M, Gold, MR. PI3K Signaling in B Cell and T Cell Biology. Front Immunol. 2014;5 :557. doi: 10.3389/fimmu.2014.00557. PubMed PMID:25404931 PubMed Central PMC4217509.

Ali, K, Soond, DR, Pineiro, R, Hagemann, T, Pearce, W, Lim, EL et al.. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014;510 (7505):407-411. doi: 10.1038/nature13444. PubMed PMID:24919154 PubMed Central PMC4501086.

Burger, JA, Okkenhaug, K. Haematological cancer: idelalisib-targeting PI3Kδ in patients with B-cell malignancies. Nat Rev Clin Oncol. 2014;11 (4):184-6. doi: 10.1038/nrclinonc.2014.42. PubMed PMID:24642682 PubMed Central PMC4536758.

Attridge, K, Kenefeck, R, Wardzinski, L, Qureshi, OS, Wang, CJ, Manzotti, C et al.. IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells. J Immunol. 2014;192 (5):2195-201. doi: 10.4049/jimmunol.1302082. PubMed PMID:24470500 PubMed Central PMC3932810.

Okkenhaug, K. Two birds with one stone: dual p110δ and p110γ inhibition. Chem Biol. 2013;20 (11):1309-10. doi: 10.1016/j.chembiol.2013.11.002. PubMed PMID:24267274 PubMed Central PMC4523579.

Angulo, I, Vadas, O, Garçon, F, Banham-Hall, E, Plagnol, V, Leahy, TR et al.. Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science. 2013;342 (6160):866-71. doi: 10.1126/science.1243292. PubMed PMID:24136356 PubMed Central PMC3930011.

Zotes, TM, Spada, R, Mulens, V, Pérez-Yagüe, S, Sorzano, CO, Okkenhaug, K et al.. PI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levels. PLoS One. 2013;8 (8):e72960. doi: 10.1371/journal.pone.0072960. PubMed PMID:24009720 PubMed Central PMC3757018.

Bouabe, H, Okkenhaug, K. A protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells. Methods Mol Biol. 2013;1064 :337-54. doi: 10.1007/978-1-62703-601-6_24. PubMed PMID:23996269 PubMed Central PMC4526796.

Bouabe, H, Okkenhaug, K. Gene targeting in mice: a review. Methods Mol Biol. 2013;1064 :315-36. doi: 10.1007/978-1-62703-601-6_23. PubMed PMID:23996268 PubMed Central PMC4524968.

Okkenhaug, K. Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity. Ann N Y Acad Sci. 2013;1280 :24-6. doi: 10.1111/nyas.12027. PubMed PMID:23551098 PubMed Central PMC4523620.

Okkenhaug, K. Signaling by the phosphoinositide 3-kinase family in immune cells. Annu Rev Immunol. 2013;31 :675-704. doi: 10.1146/annurev-immunol-032712-095946. PubMed PMID:23330955 PubMed Central PMC4516760.

Finlay, DK, Rosenzweig, E, Sinclair, LV, Feijoo-Carnero, C, Hukelmann, JL, Rolf, J et al.. PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med. 2012;209 (13):2441-53. doi: 10.1084/jem.20112607. PubMed PMID:23183047 PubMed Central PMC3526360.

Banham-Hall, E, Clatworthy, MR, Okkenhaug, K. The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases. Open Rheumatol J. 2012;6 :245-58. doi: 10.2174/1874312901206010245. PubMed PMID:23028409 PubMed Central PMC3460535.

Roller, A, Perino, A, Dapavo, P, Soro, E, Okkenhaug, K, Hirsch, E et al.. Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis. J Immunol. 2012;189 (9):4612-20. doi: 10.4049/jimmunol.1103173. PubMed PMID:23024273 .

Soond, DR, Slack, EC, Garden, OA, Patton, DT, Okkenhaug, K. Does the PI3K pathway promote or antagonize regulatory T cell development and function?. Front Immunol. 2012;3 :244. doi: 10.3389/fimmu.2012.00244. PubMed PMID:22912633 PubMed Central PMC3418637.

Soond, DR, Garçon, F, Patton, DT, Rolf, J, Turner, M, Scudamore, C et al.. Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma. J Immunol. 2012;188 (12):5935-43. doi: 10.4049/jimmunol.1102116. PubMed PMID:22611241 PubMed Central PMC3378038.

Ying, H, Fu, H, Rose, ML, McCormack, AM, Sarathchandra, P, Okkenhaug, K et al.. Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts. PLoS One. 2012;7 (3):e32892. doi: 10.1371/journal.pone.0032892. PubMed PMID:22479345 PubMed Central PMC3316549.

Kulkarni, S, Sitaru, C, Jakus, Z, Anderson, KE, Damoulakis, G, Davidson, K et al.. PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal. 2011;4 (168):ra23. doi: 10.1126/scisignal.2001617. PubMed PMID:21487106 .

Patton, DT, Wilson, MD, Rowan, WC, Soond, DR, Okkenhaug, K. The PI3K p110δ regulates expression of CD38 on regulatory T cells. PLoS One. 2011;6 (3):e17359. doi: 10.1371/journal.pone.0017359. PubMed PMID:21390257 PubMed Central PMC3046981.

Macintyre, AN, Finlay, D, Preston, G, Sinclair, LV, Waugh, CM, Tamas, P et al.. Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism. Immunity. 2011;34 (2):224-36. doi: 10.1016/j.immuni.2011.01.012. PubMed PMID:21295499 PubMed Central PMC3052433.

Ma, L, Mauro, C, Cornish, GH, Chai, JG, Coe, D, Fu, H et al.. Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Proc Natl Acad Sci U S A. 2010;107 (45):19461-6. doi: 10.1073/pnas.1011748107. PubMed PMID:20978210 PubMed Central PMC2984185.

Rolf, J, Bell, SE, Kovesdi, D, Janas, ML, Soond, DR, Webb, LM et al.. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol. 2010;185 (7):4042-52. doi: 10.4049/jimmunol.1001730. PubMed PMID:20826752 .

Ramadani, F, Bolland, DJ, Garcon, F, Emery, JL, Vanhaesebroeck, B, Corcoran, AE et al.. The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development. Sci Signal. 2010;3 (134):ra60. doi: 10.1126/scisignal.2001104. PubMed PMID:20699475 PubMed Central PMC3540743.

Okkenhaug, K, Fruman, DA. PI3Ks in lymphocyte signaling and development. Curr Top Microbiol Immunol. 2010;346 :57-85. doi: 10.1007/82_2010_45. PubMed PMID:20563708 PubMed Central PMC4499567.

Bjørgo, E, Solheim, SA, Abrahamsen, H, Baillie, GS, Brown, KM, Berge, T et al.. Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. Mol Cell Biol. 2010;30 (7):1660-72. doi: 10.1128/MCB.00696-09. PubMed PMID:20086095 PubMed Central PMC2838077.

Soond, DR, Bjørgo, E, Moltu, K, Dale, VQ, Patton, DT, Torgersen, KM et al.. PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. Blood. 2010;115 (11):2203-13. doi: 10.1182/blood-2009-07-232330. PubMed PMID:20081091 PubMed Central PMC3593196.

Salmond, RJ, Emery, J, Okkenhaug, K, Zamoyska, R. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol. 2009;183 (11):7388-97. doi: 10.4049/jimmunol.0902294. PubMed PMID:19917692 .

Selman, C, Tullet, JM, Wieser, D, Irvine, E, Lingard, SJ, Choudhury, AI et al.. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science. 2009;326 (5949):140-4. doi: 10.1126/science.1177221. PubMed PMID:19797661 PubMed Central PMC4954603.

Liu, D, Zhang, T, Marshall, AJ, Okkenhaug, K, Vanhaesebroeck, B, Uzonna, JE et al.. The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells. J Immunol. 2009;183 (3):1921-33. doi: 10.4049/jimmunol.0901099. PubMed PMID:19596993 .

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