News and events

Klaus presents at Global Immunotalks:

For additional talks, go to https://www.globalimmunotalks.org/

Annual lab punt

We joined up with the Roychoudhuri and Edgar labs and punted our way up to Grantchester for a pub lunch.

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells

New publication identifies RASA3 as a key mediator linking PI3K to LFA-1 activation in T cells.

BSI 2021

Several members of the lab attended the wonderful annual meeting of the British Society for Immunology in Edinburgh. Grace gave two(!) talks, Iqbal, Julius and our visiting student Fola presented posters.

New review on PI3K and integrins

Kristoffer’s review of PI3K in T Cell Adhesion and Trafficking is out in Frontiers in Immunology as part of a Research Topic on Targeting Leukocyte Trafficking: Insights and Future Directions. PI3K regulates these processes by recruiting a range of downstream molecules involved in trafficking and is of relevance to PI3K therapies. Great collaborative work with…
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Kristoffer Johansen passes his PhD Viva!

The examiners Dr Michelle Linterman and Dr Robert Koechler asked him some challenging questions, but in the end accepted the PhD thesis with very minor corrections. Congratulations Kristoffer!

Muhammad Iqbal wins posterprize!

Iqbal won the best oral presentation at the Department of Pathology annual symposium (held virtually this year).

New Review article on PI3K inhibitors!

Klaus has written a review article with his former postdoc supervisor and long-time collaborator Bart Vanhaesebroeck (UCL), along with Matthew Perry (AstraZeneca) , Jennifer Brown (Dana Farber) and Fabrice André (Gustave Roussy). This is a comprehensive review on the development and use of PI3K inhibitors, several of which are now clinically approved drugs. PI3K inhibitors…
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New paper alert

Happy to share our latest publication on PI3Kδ-interacting proteins in T cells. This work was led by Daisy Luff (former PhD student, now Postdoc at the Crick Institute in London).PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T CellsFront. Immunol., 08 March 2021 | https://doi.org/10.3389/fimmu.2021.631271