A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells
New publication identifies RASA3 as a key mediator linking PI3K to LFA-1 activation in T cells.
New review on PI3K and integrins
Kristoffer’s review of PI3K in T Cell Adhesion and Trafficking is out in Frontiers in Immunology as part of a Research Topic on Targeting Leukocyte Trafficking: Insights and Future Directions. PI3K regulates these processes by recruiting a range of downstream molecules involved in trafficking and is of relevance to PI3K therapies. Great collaborative work with…
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New Review article on PI3K inhibitors!
Klaus has written a review article with his former postdoc supervisor and long-time collaborator Bart Vanhaesebroeck (UCL), along with Matthew Perry (AstraZeneca) , Jennifer Brown (Dana Farber) and Fabrice André (Gustave Roussy). This is a comprehensive review on the development and use of PI3K inhibitors, several of which are now clinically approved drugs. PI3K inhibitors…
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New paper alert
Happy to share our latest publication on PI3Kδ-interacting proteins in T cells. This work was led by Daisy Luff (former PhD student, now Postdoc at the Crick Institute in London).PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T CellsFront. Immunol., 08 March 2021 | https://doi.org/10.3389/fimmu.2021.631271
New publication
Wood, AJ, Vassallo, AM, Ruchaud-Sparagano, MH, Scott, J, Zinnato, C, Gonzalez-Tejedo, C, Kishore, K, D’Santos, CS, Simpson, AJ, Menon, DK, Summers, C, Chilvers, ER, Okkenhaug, K, Conway Morris, A. (2020). C5a impairs phagosomal maturation in the neutrophil through phosphoproteomic remodelling. JCI Insight. :. PMID:32634128. doi: 10.1172/jci.insight.137029.
New publication:
Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation Anne-Katrien Stark, Elizabeth C. M. Davenport, Daniel T. Patton, Cheryl L. Scudamore, Bart Vanhaesebroeck, Marc Veldhoen, Oliver A. Garden and Klaus OkkenhaugJ Immunol May 15, 2020, ji2000043; DOI: https://doi.org/10.4049/jimmunol.2000043